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Description
KIF18A Recombinant Rabbit mAb (S-3310-11)Product Specification Host Rabbit Antigen KIF18A Synonyms Kinesin like protein KIF18A; Marrow stromal KIF18A (MS KIF18A) Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton, Nucleus Accession Q8NI77 Clone Number S 3310 11 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt, Mk Positive Sample HeLa, A549, Jurkat, MCF7, F9, Neuro 2a, raw264. 7, rat testis, COS 7 Purification Protein A Concentration 0. 5 mg ml
Product Specification
| Host | Rabbit |
| Antigen | KIF18A |
| Synonyms | Kinesin-like protein KIF18A; Marrow stromal KIF18A (MS-KIF18A) |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton, Nucleus |
| Accession | Q8NI77 |
| Clone Number | S-3310-11 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HeLa, A549, Jurkat, MCF7, F9, Neuro-2a, raw264.7, rat testis, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:1000 | Hu |
Background
KIF18A is a kinesin-8 family motor protein that uses ATP hydrolysis to move along microtubules, selectively accumulating at the plus ends of kinetochore fibers where it dampens their dynamics to ensure precise chromosome congression on the metaphase plate, control spindle length and tension, and coordinate subsequent cytokinesis, thereby safeguarding genomic integrity; its depletion triggers metaphase alignment errors, anaphase delay, central-spindle disorganization, and incomplete cleavage furrow formation, while its overexpression is strongly linked to aggressive cancers with chromosomal instability, making it a promising selective therapeutic target for small-molecule inhibitors that induce mitotic catastrophe preferentially in aneuploid tumor cells.
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