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Description
Alexa Fluor® 647 Armenian hamster Anti-Mouse CD272 Antibody (S-R709)Product Specification Host Armenian hamster Antigen CD272 Synonyms B and T lymphocyte attenuator; B and T lymphocyte associated protein; Btla Location Cell membrane Accession Q7TSA3 Clone Number S R709 Antibody Type Recombinant mAb Isotype IgG Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 0. 05mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS, 25% Glycerol, 1%
Product Specification
| Host | Armenian hamster |
| Antigen | CD272 |
| Synonyms | B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; Btla |
| Location | Cell membrane |
| Accession | Q7TSA3 |
| Clone Number | S-R709 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD272, also known as B- and T-lymphocyte attenuator (BTLA), is an inhibitory receptor belonging to the CD28 immunoglobulin superfamily. It is encoded by the BTLA gene and primarily expressed on B cells, T cells, macrophages, and dendritic cells. BTLA plays a crucial role in regulating immune responses by acting as a negative regulator of antigen receptor signaling. Its ligand is HVEM (herpesvirus entry mediator, also known as CD270), and their interaction inhibits T cell and B cell activation, proliferation, and cytokine production. Structurally, BTLA is similar to other immune checkpoint proteins like PD-1 and CTLA-4, containing an extracellular IgV-like domain and intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that mediate its inhibitory functions. BTLA's signaling involves the recruitment of tyrosine phosphatases SHP-1 and SHP-2, which dampen immune activation. Due to its role in immune regulation, the BTLA-HVEM axis is considered a promising target for cancer immunotherapy.
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