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Description
ROR1 His Tag Protein, CanineProduct Specification Species Canine Synonyms NTRKR1, Receptor Tyrosine Kinase Like Orphan Receptor 1, Neurotrophic Tyrosine Kinase, Receptor Related 1 Accession XP_038521907. 1 Amino Acid Sequence Glu48 Tyr423, with C terminal His Expression System HEK293 Molecular Weight 55 70kDa (Reducing) Purity >95% by SDS PAGE &>95% by RP HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7.
Product Specification
| Species | Canine |
| Synonyms | NTRKR1, Receptor Tyrosine Kinase Like Orphan Receptor 1, Neurotrophic Tyrosine Kinase, Receptor-Related 1 |
| Accession | XP_038521907.1 |
| Amino Acid Sequence | Glu48-Tyr423, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 55-70kDa (Reducing) |
| Purity | >95% by SDS-PAGE &>95% by RP-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Quezada M J. et al. (2023) The signaling pathways activated by ROR1 in cancer. Cell Signal. 104: 110588. |
Background
The receptor tyrosine kinase orphan receptor 1 (ROR1) serves as a receptor for WNT5A and related Wnt proteins, which are crucial during embryonic development. They regulate processes such as cell migration, cell polarity, neural patterning, and organogenesis. ROR1 mediates these functions by transducing signals from the Wnt secreted glycoproteins to the intracellular Wnt/PCP and Wnt/Ca++ pathways.
In adult human cells, especially in cancer cells, research has shown that the WNT5A/ROR1 axis can activate a variety of signaling pathways in addition to the aforementioned ones. These include the PI3K/AKT, MAPK, NF-κB, STAT3, and Hippo pathways. Furthermore, ROR1 is often aberrantly expressed in cancer and has been linked to tumor progression and poor patient survival outcomes. Its role in promoting cell proliferation, survival, invasion, epithelial-to-mesenchymal transition (EMT), and metastasis is significant.
As a result, ROR1 has emerged as a potential therapeutic target, and numerous tools aimed at targeting ROR1 are currently under evaluation in clinical trials for cancer patients.
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