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Description
CCR7 Recombinant Rabbit mAb (S-R333)Product Specification Host Rabbit Antigen CCR7 Synonyms C C chemokine receptor type 7, C C CKR 7, CC CKR 7, CCR 7, BLR2, CDw197, Epstein Barr virus induced G protein coupled receptor 1 (EBI1; EBV induced G protein coupled receptor 1), MIP 3 beta receptor, CD197, CMKBR7, EBI1, EVI1 Location Cell membrane Accession P32248 Clone Number S R333 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC, ICFCM Reactivity Hu, Ms, Rt Purification Protein A
Product Specification
| Host | Rabbit |
| Antigen | CCR7 |
| Synonyms | C-C chemokine receptor type 7, C-C CKR-7, CC-CKR-7, CCR-7, BLR2, CDw197, Epstein-Barr virus-induced G-protein coupled receptor 1 (EBI1; EBV-induced G-protein coupled receptor 1), MIP-3 beta receptor, CD197, CMKBR7, EBI1, EVI1 |
| Location | Cell membrane |
| Accession | P32248 |
| Clone Number | S-R333 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| ICC | 1:500 | null |
| ICFCM | 1:50 | null |
Background
CCR7 is a transmembrane protein with 7 transmembrane domains, which is coupled with heterotrimeric G proteins, which transduce the signal downstream through various signaling cascades. The main function of the receptor is to guide immune cells to immune organs (lymph nodes, thymus, spleen) by detecting specific chemokines, which these tissues secrete. The receptor is expressed mostly on adaptive immune cell types, namely thymocytes, naive T and B cells, regulatory T cells, central memory lymphocytes, but also dendritic cells. CCR7 has been shown to stimulate dendritic cell maturation. CCR7 is also involved in homing of T cells to various secondary lymphoid organs such as lymph nodes and the spleen as well as trafficking of T cells within the spleen.
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