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Description
Alexa Fluor® 488 Rat Anti-Mouse CD198 Antibody (S-R626)Product Specification Host Rat Antigen CD198 Synonyms C C chemokine receptor type 8; C C CKR 8; CC CKR 8; CCR 8; CDw198; Cmkbr8; Ter1; Ccr8 Location Cell membrane Accession P56484 Clone Number S R626 Antibody Type Rat mAb Isotype IgG2b,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse thymocytes Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin
Product Specification
| Host | Rat |
| Antigen | CD198 |
| Synonyms | C-C chemokine receptor type 8; C-C CKR-8; CC-CKR-8; CCR-8; CDw198; Cmkbr8; Ter1; Ccr8 |
| Location | Cell membrane |
| Accession | P56484 |
| Clone Number | S-R626 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse thymocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD198, also known as CCR8, is a 41 kD G-protein coupled receptor with seven transmembrane regions, belonging to the C-C chemokine receptor family. It is predominantly expressed in lymphoid tissues, including subsets of T cells, monocytes, macrophages, eosinophils, thymocytes, Langerhans cells, neurons, and vascular smooth muscle cells. CCR8 plays a crucial role in regulating monocyte chemotaxis, thymic cell apoptosis, and the activation, migration, proliferation, and differentiation of lymphocytes. It is also associated with allergic diseases and has been identified as an alternative coreceptor to CD4 for HIV-1 infection. CCR8 binds to chemokines such as CCL1 (I-309) and CCL18 and exhibits high affinity for viral chemokines like vMIP-I, vMIP-II, and vMCC-I.
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Exchange/Return Notes
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