SKU: 14979191633

Mouse Anti-Human HLA-E Antibody (S-3810)

Sale price$90.00 Regular price$100.00
Save 10%

Pay in installments of $25.00 with ShopPay, AfterPay and Klarna

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Aug 23 - Aug 28

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

Mouse Anti-Human HLA-E Antibody (S-3810)Product Specification Host Mouse Antigen HLA E Synonyms HLA class I histocompatibility antigen, alpha chain E; MHC class I antigen E; HLA 6. 2; HLAE Location Cell membrane Accession P13747 Clone Number S 3810 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human peripheral blood cells Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability

Product Specification


Host Mouse
Antigen HLA-E
Synonyms HLA class I histocompatibility antigen, alpha chain E; MHC class I antigen E; HLA-6.2; HLAE
Location Cell membrane
Accession P13747
Clone Number S-3810
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample Human peripheral blood cells
Purification Protein G
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1:200 Hu

Background

HLA-E is a non-classical, oligomorphic class Ib major histocompatibility complex (MHC) molecule whose primary function centers on presenting highly conserved nonameric signal peptides (predominantly the VMAPRTLVL sequence, known as VL9) derived from the leader sequences of other classical HLA class I molecules (such as HLA-A, -B, -C, and -G) via a TAP-dependent processing pathway. These peptides form stable peptide-HLA-E-β2m trimers that are transported to the cell membrane, where they serve as key ligands for the CD94/NKG2 family of receptors expressed on NK cells and certain CD8⁺ T cells. Notably, HLA-E exhibits significantly higher affinity for the inhibitory receptor NKG2A than for the activating receptor NKG2C. This mechanism constitutes a real-time "sensing system" that monitors the overall expression levels of classical MHC-I molecules within the cell, enabling the immune system to recognize and eliminate "missing-self" cells—those that have downregulated classical MHC-I due to viral infection or malignant transformation. Unlike classical HLA molecules, HLA-E displays extremely low genetic polymorphism (predominantly represented by the E01:01 and E01:03 alleles), minimal surface expression levels, and a remarkably short half-life (approximately 12 minutes). Its cytoplasmic tail contains a unique lysine/tryptophan motif that drives clathrin-mediated rapid endocytosis via the adaptor protein AP-2, followed by endosomal peptide exchange and recycling through VCP-associated pathways. This unconventional intracellular trafficking mechanism enables HLA-E, under specific conditions (such as macrophages infected with mycobacteria or CMV-vectored vaccine strategies), to load suboptimal peptides derived from stress protein Hsp60 signal sequences or from pathogens including Mycobacterium, Salmonella, HIV, and SARS-CoV-2. These peptides are presented in an HLA-E-restricted manner to CD8⁺ T cells expressing TCRs featuring the unique TRAV17 gene segment, thereby eliciting adaptive immune responses. Given its dual role as both a central hub maintaining NK cell tolerance and a shared target exploited by viruses (such as HCMV and HIV) and tumors (which upregulate HLA-E to retain NK inhibitory signals and evade immunity), HLA-E has emerged as a critical target for developing "universal" T cell/NK cell immunotherapies and for designing novel CMV-vectored vaccines—exemplified by the clearance of SIV in rhesus macaques within the RhCMV/SIV model.

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 14979191633

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.5 ★★★★★
Based on 23 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
W
Verified Purchase
Wisconsin Customer
Massapequa, US
★★★★★ 5
Work great, no morning groggy, made in USA
Flavor Name: Peppermint
These make me sleep like a baby! I am 52 and often could not turn my brain off to go to sleep or stay asleep at night. About 30-45 minutes after taking these my head hits the pillow and I’m out! I take 3 tablets / 15 mg. No groggy feeling in the morning. My previous experience with melatonin had been gummies - 10-12 mg and did not work as well. Taste was also inconsistent. These are a nice peppermint, like the circle-O candies we ate as a kid. A little chalky but not bad. They don’t dissolve as fast as I thought but directions say ok to chew so then they dissolve very quickly. I also like that company is fully USA for development and manufacture. Many of gummies are not. The tablet format is also very convenient to pack for travel. I have not tried full pill format by any manufacturer.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 18, 2021
T
Verified Purchase
Tina
Whiting, US
★★★★★ 5
Flavor is great, works well!
Flavor Name: Peppermint
Excellent when using 2, great flavor/taste. Thank you!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on November 29, 2025
L
Verified Purchase
Lillie
Lowell, US
★★★★★ 5
Like the dissolvable feature
Flavor Name: Peppermint
Cardiologist recommended one tablet nightly 30 minutes before bed to protect the lungs from covid. His other recommendations were standard protocol. Had never heard of this but know that melatonin is supposed to help with sleep. Had tried melatonin for sleep, at higher strength, but effect wore off after a week. Suprisingly, this seems to help with sleep as well. Large count at reasonable price.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 7, 2021
E
Verified Purchase
Edward A. Rutherford
Birmingham, US
★★★★★ 4
Sleep aid that helpd.
Flavor Name: Peppermint
I purchased these because I understand that the natural production of melatonin decreases drastically after the age of 40. I have been using another brand that much more expensive for a lower dosage. I read the other reviews and decided to give these a try. I have been taking them for about 30 days. I think, I have a good understanding of the pills. It appears that the other brand had a more consistent effect. They sublingual and you would feel drowsy after about 20 minutes. These are slow desolve and take effect after 30 minutes or so. My only issue was consistency. I would say that 90% of the time I would be drowsy. Once or twice a month they would have a minimal effect. They are a stronger dose, 5 mg versus 3 mg of the other product. They are less expensive and they work most of the time.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 16, 2024
N
Verified Purchase
Nazmo
Massapequa, US
★★★★★ 5
No after taste
Flavor Name: Peppermint
Easy on digestive system
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 16, 2025

recommand products