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Description
AACT Recombinant Rabbit mAb (S-897-109)Product Specification Host Rabbit Antigen AACT Synonyms Alpha 1 antichymotrypsin; ACT; Cell growth inhibiting gene 24 25 protein; Serpin A3; SERPINA3 Immunogen Recombinant Protein Location Secreted Accession P01011 Clone Number S 897 109 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample human serum, human plasma Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance
Product Specification
| Host | Rabbit |
| Antigen | AACT |
| Synonyms | Alpha-1-antichymotrypsin; ACT; Cell growth-inhibiting gene 24/25 protein; Serpin A3; SERPINA3 |
| Immunogen | Recombinant Protein |
| Location | Secreted |
| Accession | P01011 |
| Clone Number | S-897-109 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | human serum, human plasma |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:10000 | Hu |
| IHC-P | 1:1000 | Hu |
Background
Alpha-1-antichymotrypsin (AACT), also known as SERPINA3, is a serine protease inhibitor primarily synthesized in the liver and secreted into the blood. It is an acute-phase protein involved in the inflammatory response and has a molecular weight of approximately 47.651 kDa. AACT plays a crucial role in inhibiting proteases such as cathepsin G and chymase, thereby protecting cells and tissues from proteolytic damage. Elevated levels of AACT have been observed in various diseases, including Alzheimer's disease, heart failure, and multiple cancers. Its expression and glycosylation patterns can serve as potential biomarkers for disease diagnosis and prognosis.
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