SKU: 1465286056

Biotin Mouse Anti-Human CD170 (Siglec-5) Antibody (S-4097)

Sale price$175.50 Regular price$195.00
Save 10%

Pay in installments of $48.75 with ShopPay, AfterPay and Klarna

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Aug 25 - Aug 30

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

Biotin Mouse Anti-Human CD170 (Siglec-5) Antibody (S-4097)Product Specification Host Mouse Antigen CD170 (Siglec 5) Synonyms Sialic acid binding Ig like lectin 5; CD33 antigen like 2; Obesity binding protein 2 (OB BP2; OB binding protein 2); SIGLEC5; CD33L2; OBBP2 Location Membrane Accession O15389 Clone Number S 4097 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human Peripheral Blood cells Purification Protein G Concentration 0. 2 mg ml Conjugation Biotin Physical

Product Specification


Host Mouse
Antigen CD170 (Siglec-5)
Synonyms Sialic acid-binding Ig-like lectin 5; CD33 antigen-like 2; Obesity-binding protein 2 (OB-BP2; OB-binding protein 2); SIGLEC5; CD33L2; OBBP2
Location Membrane
Accession O15389
Clone Number S-4097
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample Human Peripheral Blood cells
Purification Protein G
Concentration 0.2 mg/ml
Conjugation Biotin
Physical Appearance Liquid
Storage Buffer

PBS pH7.4, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

CD170 protein, also known as sialic acid-binding immunoglobulin-like lectin-5 (Siglec-5), is a type I transmembrane inhibitory receptor primarily expressed on myeloid cells (such as monocytes, macrophages, and neutrophils) and some B cells. It belongs to the immunoglobulin superfamily and the Siglec family. Its extracellular region contains an immunoglobulin-like domain that specifically recognizes and binds to sialylated glycans (commonly found on host cell surfaces), while its intracellular region contains an immunoreceptor tyrosine-based inhibitory motif (ITIM). Upon binding to sialylated self-ligands, the ITIM domain of CD170 becomes phosphorylated, recruiting and activating SH2 domain-containing protein tyrosine phosphatases (e.g., SHP-1/SHP-2), thereby transmitting potent inhibitory signals that negatively regulate the activation of myeloid cells, the production of inflammatory cytokines, and phagocytic functions. This mechanism plays a critical role in maintaining immune homeostasis and preventing excessive inflammatory responses against self-tissues. In pathological conditions, certain pathogens or tumor cells can evade immune surveillance by engaging CD170 through "molecular mimicry" or "decoy" mechanisms using surface sialylated glycans, thereby promoting persistent infection or tumor progression. Thus, CD170 is not only a key regulator of immune self-tolerance but also a potential target for infection immunotherapy and cancer immunotherapy. Modulating its function—for example, using monoclonal antibodies for blockade or agonism—may offer novel therapeutic strategies for autoimmune diseases, chronic inflammation, and cancer.

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 1465286056

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.2 ★★★★★
Based on 9 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
S
Verified Purchase
Summer
Grantham, US
★★★★★ 1
Save your money
Color: Mayday
We bought this specifically for our trip to Florida and had high hopes based on all the positive reviews. Unfortunately, it was a complete disappointment. I used it on all five members of our family exactly as directed, and it did absolutely nothing for any of us. Not only was it ineffective, but it was also extremely overpriced for the results we got—which were none. We felt like we wasted our money on a product that simply doesn’t work as advertised. Looking back, I wish I hadn’t trusted the reviews and had saved my money instead. I rarely leave negative reviews, but I feel it’s important to share my experience so others can make a more informed decision. Based on our experience, I would not recommend this product.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 8, 2026
C
Verified Purchase
Cassandra
Birmingham, US
★★★★★ 5
Works
Color: Mayday
A little does go a long way. It’s on the pricy side but it was worth it. It’s not something to be using all the time. But definitely a back up for whenever you do get sunburn
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 21, 2026
D
Verified Purchase
Dreazyed
Boise, US
★★★★★ 5
Really effective!
Color: Mayday
I was totally blown away by how effective this was on my recent burn, I wish I had taken pictures. So much so that I did a deep dive into the ingredients and formula (I'm a nerd). My takeaway is that this is a bargain for the quality of ingredients and the care of the formula. The product absorbs quickly, is non-greasy, and relatively moisturizing and most of all, really effective. I personally appreciate the lack of any real scent or fragrance. I'm a big fan!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 17, 2026
C
Verified Purchase
CosmoGodiva
Battle Creek, US
★★★★★ 2
Not the results I expected
Color: Mayday
I sooo wanted to love this product; however, the results were not as I expected. Especially at this price point. I have sensitive skin & actually broke out, so maybe I am allergic to one of the ingredients or applied the product too thickly. I’ve experienced better results with Coola’s Radical Recovery Organic After Sun Lotion which is only $32 for 5oz, so it’s definitely more cost effective & delivered better results in my opinion.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 31, 2026
J
Verified Purchase
Jdsunshine
Massapequa, US
★★★★★ 5
Nothing Better
Excellent product! I have the old person dry crinkly skin for a few years. I've tried creams and Castor and coconut oils. They leave me and my clothes greasy yet doesn't stay on my skin. Where those other items failed, this Tallow Cream meets and exceeds. This goes on smooth and I look forward to the wonderful scent. I like using this cream. My hands and arms look and feel healthy. Better then it ever looked really. I'm not embarrassed by my skin now. My husband tried this on his face and beard. Very nice. He has his own jar of this Tallow cream now. About the ADDED ingredients they put in the cream... it's all good things, proof is how well it works. I don't want to make any changes to it and I would. My husband tried on his face and beard. He has his own jar now. I look to reviews for product insights. I hope our reactions help.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 30, 2025

recommand products