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Description
Biotin Mouse Anti-Human CD146 Antibody (S-3679)Product Specification Host Mouse Antigen CD146 Synonyms Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma associated antigen A32; Melanoma associated antigen MUC18; S endo 1 endothelial associated antigen; MUC18; MCAM Location Membrane Accession P43121 Clone Number S 3679 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample HeLa Purification Protein G
Product Specification
| Host | Mouse |
| Antigen | CD146 |
| Synonyms | Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; MUC18; MCAM |
| Location | Membrane |
| Accession | P43121 |
| Clone Number | S-3679 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | HeLa |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD146, also known as melanoma cell adhesion molecule (MCAM), is a 113-kDa, heavily glycosylated type-I transmembrane glycoprotein of the immunoglobulin superfamily that consists of five Ig-like domains (V-V-C2-C2-C2), a single transmembrane segment and a cytoplasmic tail existing in a long and a short splice isoform; initially identified on melanoma cells, it now is recognized as a multifunctional adhesion and signaling receptor widely expressed on endothelial cells, pericytes, smooth muscle, activated T cells and various stem cells that, through homophilic interactions and ligands such as laminin-411, Wnt5a and galectin-1, orchestrates angiogenesis, vascular integrity, cell migration, immune-cell trafficking and epithelial–mesenchymal transition, while its overexpression and elevated glycosylation in melanoma, renal, prostate, lung, pancreatic and other cancers correlate with tumor progression, metastasis and poor prognosis, and its soluble ectodomain (sCD146) released by metalloprotease shedding functions as a circulating biomarker, making CD146 a valuable diagnostic and therapeutic target in oncology and inflammatory diseases.
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4.2 ★★★★★
Based on 7 reviews
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Product Reviews
★★★★★ 4
Versatile spray that works well for sensitive skin
Lately I've been hearing so much about hypochlorus acid and its multiple benefits and uses. Being that I really like Coola products, when I saw that Coola had made a hypochlorous acid face spray, I was eager to give it a try. I'm glad I did!
As someone with sensitive skin that gets irritated from perspiration when I work out, I was hoping this spray might calm my post-workout skin...and it did. The mist comes in an attractive spray bottle. The spray that comes out is at the intensity of somewhere between a fine mist and a coarse spray; it sprays a good amount to wet your face rather than just a very fine coating. Upon spraying on my skin that was red and warm from my workout, I immediately felt a cooling effect. I wiped the spray in to my skin a bit, and it both cleared away the perspiration, and felt soothing to my post-workout irritation. It felt very different from other toners or astringents I'd used, and my face felt clean, refreshed and unexpectedly soft after use.
I later tried the recovery mist on a small area of rash I developed on my neck. I had a similar experience in that it cooled the skin, and my rash appeared minimized, as well.
My only issue with this product is the scent. The spray has a scent that smells like a faint version of chlorine bleach...which was disconcerting, since I'm spraying it on my face! I actually looked it up and apparently that's just the scent that hypochlorous acid has...so it's not specific to just Coola's product. Fortunately, the bleachy scent dissipated quickly.
Overall, I'm happy with this product, and found it useful for my irritated skin. While I tried it for post workout skin and a rash, apparently it can be used for bites, scrapes and acne as well, so it seems to be very versatile. So if you can get over the initial bleachy scent, it's definitely worth giving a try. Priced at $20 for the 3.4 ounce bottle, which should last a while, I find it to offer a good value for the money, as well.
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Reviewed in the United States on March 6, 2026
★★★★★ 5
Surprisingly Effective for Redness & Post-Sun Skin Recovery
This stuff actually works. I’ve been using it after sun exposure, and it genuinely seems to help calm, soothe, and hydrate my skin.
I usually spray it on before applying my hydrating serums and moisturizer, so it’s part of a larger skincare routine, but I definitely feel like this mist plays an important role. My skin feels less irritated, looks less red, and just overall more refreshed afterward.
The spray itself is lightweight and easy to use, with no sticky residue or heavy feeling on the skin. It layers well with other skincare products too, which I appreciate.
Overall, this has become a really nice recovery step in my routine—especially after being outdoors or whenever my skin feels stressed and dehydrated. Sometimes skincare products make very dramatic promises and deliver absolutely nothing but scented disappointment. This one quietly does its job.
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Reviewed in the United States on May 21, 2026
★★★★★ 5
Truly refreshing right away
I am someone who gets a red face from even the most slight physical exertion, even when I'm in peak physical shape (I've been this way my entire life), so anything that reduces redness and heat is something I'll pretty much instantly try. I already use several other Coola products (their hair sunscreen is amazing) so this was interesting right away. After going on a brisk walk pushing the stroller (while pregnant by the way), I tried this spray on my face and chest. It was genuinely refreshing immediately! It didn't bother my skin, was a good amount of product in one spray, and didn't have any kind of weird smell. Honestly for $20, I would buy this repeatedly every spring/summer, especially in the Midwest! I'm considering ordering an extra bottle just for my daughter to take with her to summer camp. Pro tip: store in the fridge for even more refreshing-ness!
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Reviewed in the United States on April 17, 2026
★★★★★ 4
Amazing ability to calm red, itchy skin but pricier than alternatives
When I saw this product, I was a bit skeptical. I have extremely dry skin that’s prone to red, itchy spots but it seemed unlikely a misty spray would be anywhere near as beneficial as the creams and ointments I’ve turned to over the years. Since I’ve used other COOLA products and really liked them, I decided to give it a try and I was pleasantly surprised. I tried it on a couple of red patches on my face. There’s an immediate feeling of cooling relief (which leads me to believe this would also be a great solution for a burn), but what I found amazing was the redness decreased significantly and immediately. After a few minutes, I was able to put on makeup, forgoing concealer on those spots. I also tried it on a red, itchy spot on my leg, again calming the itch and decreasing the redness.
Just because it seemed unwise to start using hypochlorous acid, the active ingredient in this spray, knowing nothing about it, I did a bit of online research. Apparently, not only is it considered safe and recommended by dermatologists for eczema like conditions, it also is antibacterial and can be used to keep cuts clean and help them heal. I’m sold on the concept of this spray. My one hesitation is that it seems to be more expensive than other similar options – particularly when you do the math to determine cost per ounce. I am a real fan of the COOLA brand, but given that my skin is such that I’ll probably use this regularly, the cost differential may become prohibitive.
I would highly recommend this product for anyone who wants it on hand for the occasional sunburn or blemish. For those like me who would benefit by using it once or more per day, while still singing its praises as to efficacy, I would have to qualify the recommendation due to price.
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Reviewed in the United States on March 4, 2026
★★★★★ 5
Refreshing, Recovery Mist
I’ve been using this COOLA Recovery+ Face Mist right after running, and it does wonders. After a run, my face usually looks flushed and feels a bit irritated from sweat and heat. A couple sprays of this helps tremendously. It provides an immediate cooling and refreshing feel without irritation. It really helps reduce that post run redness faster and it feels very gentle. It’s super easy to use. You just spray it on and let it dry.
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Reviewed in the United States on April 23, 2026
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