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Description
Phospho-IκBα (Ser36) Recombinant Rabbit mAb (S-R102)Product Specification Host Rabbit Antigen Phospho IB (Ser36) Synonyms Phospho NF kappa B inhibitor alpha+ (Ser36), Phospho I kappa B alpha (Ser36), Phospho IkB alpha (Ser36), Phospho IkappaBalpha (Ser36), Phospho IKBA (Ser36), Phospho MAD3 (Ser36), Phospho NFKBIA (Ser36) Location Cytoplasm, Nucleus Accession P25963 Clone Number S R102 Antibody Type Rabbit mAb Application WB, IHC P, ICC, ICFCM Reactivity Hu Purification Protein A Concentration 0. 5 mg
Product Specification
| Host | Rabbit |
| Antigen | Phospho-IκBα (Ser36) |
| Synonyms | Phospho-NF-kappa-B inhibitor alpha+ (Ser36), Phospho-I-kappa-B-alpha (Ser36), Phospho-IkB-alpha (Ser36), Phospho-IkappaBalpha (Ser36), Phospho-IKBA (Ser36), Phospho-MAD3 (Ser36), Phospho-NFKBIA (Ser36) |
| Location | Cytoplasm, Nucleus |
| Accession | P25963 |
| Clone Number | S-R102 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IHC | 1:2000 | null |
| ICFCM | 1:5000 | null |
| ICC | 1:500 | null |
Background
The IκBα (inhibitor of nuclear factor kappa B) protein inactivates the NF-κB transcription factor by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm [PMID: 9865693, PMID: 9244310, PMID: 9346484]. Activation occurs via phosphorylation of IκBα at Ser32 and Ser36 followed by proteasome-mediated degradation that results in the release and nuclear translocation of active NF-κB [PMID: 7739562]. Specifically, IKK phosphorylates the inhibitory IκBα protein [PMID: 10602462]. This phosphorylation results in the dissociation of IκBα from NF-κB. NF-κB, which is now free, migrates into the nucleus and activates the expression of at least 150 genes; some of which are anti-apoptotic.
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