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Description
ROR2 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms ROR2, NTRKR2, Receptor Tyrosine Kinase Like Orphan Receptor 2, BDB1 Accession A1L4F5 Amino Acid Sequence Glu34 Gly403, with C terminal Human IgG1 Fc
Product Specification
| Species | Human |
| Synonyms | ROR2, NTRKR2, Receptor Tyrosine Kinase Like Orphan Receptor 2, BDB1 |
| Accession | A1L4F5 |
| Amino Acid Sequence | Glu34-Gly403, with C-terminal Human IgG1 Fc EVEVLDPNDPLGPLDGQDGPIPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDARSRAPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK |
| Expression System | HEK293 |
| Molecular Weight | 52-61kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Liu Y. et al. (2007) Homodimerization of Ror2 tyrosine kinase receptor induces 14-3-3(beta) phosphorylation and promotes osteoblast differentiation and bone formation. Mol Endocrinol. 21: 3050-3061. 2、Afzal A R. et al. (2000) Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2. Nat Genet. 25: 419-422. 3、van Bokhoven H. et al. (2000) Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome. Nat Genet. 25: 423-426. |
Background
Tyrosine-protein kinase transmembrane receptor ROR2 is also known as Neurotrophic tyrosine kinase, receptor-related 2 (NTRKR2), which belongs to the protein kinase superfamily and Tyr protein kinase family and ROR subfamily. ROR2 is broadly expressed during embryonic development and can be found in cells of all three germ layers as well as in most organ tissues. ROR2 binds the Wnt family ligand, Wnt-5a, to activate non-canonical Wnt signaling pathways. Activation of ROR2 signaling promotes cellular proliferation, differentiation, cell-polarization, and migration. ROR2 is important for osteogenic and chondrogenic differentiation of mesenchymal stem cells. ROR2 is also involved in neurite outgrowth and synapse development in the brain.
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4.1 ★★★★★
Based on 8 reviews
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Product Reviews
★★★★★ 1
Auto-Rolling Dog Ball - loud with a mystery filling.
I got this to entertain my high energy dog and she does like it, but I don't.
The ball is incredibly loud and doesn't move around nearly as much as I had hoped. When your dog picks it up, it turn their mouth into an amplifier making it louder.
It bounces/vibrates around more than rolling. Which is not what I expected, but seems to be engaging enough for more dog (but that doesnt take much).
What I really dislike is there is no way on the exterior to know what mode you are in and the inside is full of grease. To charge it and to see the lights to identify what mode it is involves opening it and touching the grease covered insides. The lights don't seem to match the instructions when trying to switch modes. The light is supposed to stay on for 3s. It doesn't for either mode and immediately cycles through other colors making it more confusing.
The exterior seems durable enough for a moderate chewer and I like the color and texture.
At $15, it seems like a fair price, but I can't recommend this at any price point. I don't feel comfortable letting my dogs play with toys that could easily expose them to an unidentified grease. Any greased components should be sealed. Not somewhere I have to touch for normal operation and potentially leak.
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Reviewed in the United States on April 4, 2026
★★★★★ 5
Gentle vibrations and rolling
My sweet old man dog didnt know what to think of this at first. We introduced it to him without turning it on at first, like a regular ball. That was fine, he was good with that and he liked to go chasing it (its heavy because its mechanical so I wouldnt throw it, a light toss/roll is how we started).
After we played that way a while we turned it on. At first he was confused as to why his toy was chasing him. It mostly vibrates and bops around a bit. But then my pup started chasing it and kicking it around like a little soccer ball and he LOVED THAT. A charge lasts quite a while too and if he doesnt play with it in for a few minutes it goes to sleep so its not just bouncing constantly and driving me crazy.
My pup likes it and it gives me a rest from the constant throwing so I'm happy!
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Reviewed in the United States on April 7, 2026
★★★★★ 5
Keeps My Dog Entertained for Hours!
This auto-rolling dog ball has been a total game changer for keeping my dog busy and active! The second I turned it on, my dog was instantly curious and started chasing it all over the house. It moves and rotates in a really fun, unpredictable way that keeps their attention much longer than regular toys.
I love that it helps with boredom relief, especially on days when we can’t get outside as much. It’s perfect for indoor play but also works great outside too. The material feels durable and holds up well against chewing, which is a must for my pup.
The USB rechargeable feature is super convenient—no constantly replacing batteries—and it holds a charge long enough for multiple play sessions. I also appreciate that it’s easy to clean and has some water resistance, so I don’t have to worry too much about slobber or a little outdoor use.
Overall, this is a fun, interactive toy that actually keeps dogs engaged and moving. Highly recommend for anyone with an energetic or easily bored pup!
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Reviewed in the United States on April 5, 2026
★★★★★ 5
Great toy!
Pattern Name: Carrot
"Dog toys by Dole? The banana people??" Yep, me too. My dog loves this toy. The plastic piece is a great texture for chewing. The stuffy is small enough for most puppies and will grow to medium sized dogs. The green of the carrot crinkles and they both wash up good. The stuffy has been through the wash many times. Good quality, durable toys.
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Reviewed in the United States on June 4, 2026
★★★★★ 4
The plastic is easy to chew through
Pattern Name: Carrot, Pattern Name: Carrot
Taking off one star on what would otherwise be a five-star product because dogs can chew off small plastic pieces fairly easily. Other than that, my dogs went wild for this toy and loved playing with it and chewing on it for hours.
If your dog isn’t a heavy chewer, I’d definitely recommend it. Otherwise, close supervision is strongly advised.
That said, I really like the other materials used, the crinkly fabric carrot top is especially fun and engaging for dogs.
Overall, I think this would be an even better product if the material for the carrot base were made from a harder, more durable plastic.
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Reviewed in the United States on May 20, 2026