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Description
ALDH1A1 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen ALDH1A1 Synonyms Aldehyde dehydrogenase 1A1; 3 deoxyglucosone dehydrogenase; ALDH E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase; cytosolic; Retinal dehydrogenase 1 (RALDH 1; RalDH1); ALDC; ALDH1 Immunogen Synthetic Peptide Location Cytoplasm Accession P00352 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P Reactivity Hu, Ms Positive Sample HepG2, HT 29, A549,
Product Specification
| Host | Rabbit |
| Antigen | ALDH1A1 |
| Synonyms | Aldehyde dehydrogenase 1A1; 3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase; cytosolic; Retinal dehydrogenase 1 (RALDH 1; RalDH1); ALDC; ALDH1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | P00352 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms |
| Positive Sample | HepG2, HT-29, A549, mouse liver, mouse lung |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| IHC-P | 1:250 | Hu, Ms |
Background
Aldehyde dehydrogenase 1A1 (ALDH1A1) is an NADP-dependent enzyme belonging to the ALDH family, playing a crucial role in various physiological and toxicological processes. It is widely recognized as a marker for tumor-initiating cells and is involved in maintaining the stemness of tumor cells, promoting tumor angiogenesis and metastasis, and contributing to resistance against anticancer drugs. ALDH1A1 also lowers intracellular pH in breast cancer cells, suppressing antitumor immunity and fostering cancer progression. Recent studies have shown that ALDH1A1 upregulates ZBTB7B, a transcription factor that promotes glycolysis in tumor cells, leading to increased lactate production and immune evasion. This highlights ALDH1A1's potential as a therapeutic target for cancer immunotherapy.
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