SKU: 12536163618

Magnesium Bisglycinate

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Description

Magnesium BisglycinateMagnesium is an essential mineral required for hundreds of biochemical reactions that govern energy production, neuromuscular function, cardiovascular health, and metabolic balance. Yet inadequate magnesium intake remains common due to modern dietary patterns, environmental factors, and increased physiological demands from stress and physical activity. Magnesium bisglycinatea chelated form of magnesium bound to the amino acid glycineis widely

Magnesium is an essential mineral required for hundreds of biochemical reactions that govern energy production, neuromuscular function, cardiovascular health, and metabolic balance. Yet inadequate magnesium intake remains common due to modern dietary patterns, environmental factors, and increased physiological demands from stress and physical activity. Magnesium bisglycinate—a chelated form of magnesium bound to the amino acid glycine—is widely recognized for its superior absorption, excellent gastrointestinal tolerance, and calming neuromuscular effects. This highly bioavailable form is designed to efficiently restore magnesium status while supporting relaxation, recovery, sleep quality, and overall systemic wellness.

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FULL SCIENCE

Magnesium is an essential mineral involved in over 300 enzymatic reactions in the body, supporting energy production, neuromuscular coordination, cardiovascular function, and metabolic health. Despite its importance, inadequate intake is common due to modern diets, stress, and high physical demands.

Magnesium bisglycinate is a chelated form in which magnesium is bound to the amino acid glycine. This structure enhances absorption and improves gastrointestinal tolerance by utilizing amino acid transport pathways rather than relying solely on passive mineral absorption. As a result, it delivers consistent systemic magnesium levels with minimal laxative effects compared to poorly absorbed forms like magnesium oxide, making it ideal for daily or higher-dose supplementation.

At the cellular level, magnesium is required for biologically active ATP, directly supporting energy metabolism, muscular performance, and recovery. It also plays a role in insulin signaling and glucose regulation, contributing to metabolic stability. In muscle tissue, magnesium acts as a natural calcium antagonist, promoting proper contraction and relaxation and helping reduce cramps and tension.

Magnesium is equally important for nervous system balance, regulating NMDA receptors and supporting GABA activity to maintain healthy excitation–relaxation dynamics. The glycine component further supports calmness and sleep quality. Additionally, magnesium contributes to cardiovascular health by promoting vascular relaxation and healthy blood pressure.

Overall, magnesium bisglycinate is a highly bioavailable, well-tolerated form that supports performance, recovery, metabolic function, sleep, and long-term wellness.

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REFERENCES

Nielsen FH. Magnesium deficiency and increased inflammation: current perspectives. Journal of Inflammation Research. 2018;11:25–34.

Volpe SL. Magnesium in disease prevention and overall health. Advances in Nutrition. 2013;4(3):378S–383S.

Rosanoff A, Weaver CM, Rude RK. Suboptimal magnesium status in the United States: are the health consequences underestimated? Nutrition Reviews. 2012;70(3):153–164.

Cuciureanu MD, Vink R. Magnesium and stress. Magnesium Research. 2011;24(3):S37–S44.

Boyle NB, Lawton C, Dye L. The effects of magnesium supplementation on subjective anxiety and stress—A systematic review. Nutrients. 2017;9(5):429.

Uwitonze AM, Razzaque MS. Role of magnesium in vitamin D activation and function. Journal of the American Osteopathic Association. 2018;118(3):181–189.

Schwalfenberg GK, Genuis SJ. The importance of magnesium in clinical healthcare. Scientifica. 2017;2017:4179326.

DiNicolantonio JJ, O’Keefe JH, Wilson W. Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis. Open Heart. 2018;5(1):e000668.

Zhang X, Li Y, Del Gobbo LC, et al. Effects of magnesium supplementation on blood pressure: a meta-analysis of randomized controlled trials. Hypertension. 2016;68(2):324–333.

Barbagallo M, Dominguez LJ. Magnesium and type 2 diabetes. World Journal of Diabetes. 2015;6(10):1152–1157.

de Baaij JHF, Hoenderop JGJ, Bindels RJM. Magnesium in man: implications for health and disease. Physiological Reviews. 2015;95(1):1–46.

Walker AF, Marakis G, Christie S, Byng M. Mg citrate found more bioavailable than other Mg preparations in a randomised, double-blind study. Magnesium Research. 2003;16(3):183–191.

Ranade VV, Somberg JC. Bioavailability and pharmacokinetics of magnesium after administration of magnesium salts to humans. American Journal of Therapeutics. 2001;8(5):345–357.

Abbasi B, Kimiagar M, Sadeghniiat-Haghighi K, et al. The effect of magnesium supplementation on primary insomnia in elderly subjects. Journal of Research in Medical Sciences. 2012;17(12):1161–1169.

Wienecke E, Nolden C. Glycine and sleep quality—mechanistic considerations and clinical implications. Sleep and Biological Rhythms. 2016;14(1):3–9.

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SKU: 12536163618

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Wolf-Haven
West Palm Beach, US
★★★★★ 5
Perfect for ball demolishers
Size: Medium
The dogs love the chuck it brand. I don’t know what it’s made of but they go crazy over them. Will not play with another ball. Wonder if it’s “laced” with an addictive scent. Have pits. Very durable. Not able to chew to pieces. Last for about 6 months before there is a small break. I keep a back up because when the ball goes missing the house is in chaos. 😆 🤪
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 27, 2026
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Verified Purchase
Tatiana
Natrona Heights, US
★★★★★ 5
Most durable ball!
Size: Medium
This are my dogs fav ball 😍 they last forever!
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Reviewed in the United States on April 23, 2026
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Nana
Dallas, US
★★★★★ 4
Chuckit medium rebound balls
Size: Medium
My 8 month old German shepherd dog loves these balls. They are easy to throw, they bounce great, they are very chewable! She keeps one in her mouth most of the time. It satisfies her need to chew and she does not chew other things. She drops it in the water and lets the hole fill up and drinks that way. The only problem that has caused is suction in her mouth and difficulty in dislodging it for her. However, she would be lost without it!
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Reviewed in the United States on April 19, 2023
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Verified Purchase
Helena
Dallas, US
★★★★★ 5
These are definitely indestructible
Size: Medium
Both of my dogs can destroy a ball in a matter of minutes if I let them play with them (supervised) as is. Well not with these balls. They are the ONLY ones I have found that are 100% indestructible. Please only let your dogs play with these as a toy when supervised though. They go really far when throwing them, so both dogs get a good amount of running and exercise with these. I also bought these because they have the hole in the middle of the ball which is very important in the event that a dog gets one stuck at the back of their throat. This allows them to breath unlike those without this hold. It's an unlikely event, but as dog owners, we all need to be aware of this and educate ourselves on what to do if this SHOULD happen. This isn't a scare tactic, nor a reflection of this particular brand, it can happen with any type of ball. My two dogs are about 45ish lbs and the size is perfect for them, I don't want anything smaller than this. They love them. There is no annoying squeak. Really easy to wash after use. Some balls take forever to get the slimy saliva off, but these don't.
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Reviewed in the United States on September 25, 2025
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Ale quintero
Whiting, US
★★★★★ 5
He loves this ball
Size: Medium, Size: Medium
My dog loves this ball. It’s the perfect size, he enjoys playing fetch and this ball has been his fav one. Thank you guys for making my lil one happy
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Reviewed in the United States on May 2, 2026

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