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Description
Rat Anti-Mouse/Human CD49f Antibody (S-R707)Product Specification Host Rat Antigen CD49f Synonyms Integrin alpha 6; CD49 antigen like family member F; VLA 6; ITGA6 Location Cell membrane Accession P23229Q61739 Clone Number S R707 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Hu, Ms Positive Sample Human peripheral blood lymphocytes Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12
Product Specification
| Host | Rat |
| Antigen | CD49f |
| Synonyms | Integrin alpha-6; CD49 antigen-like family member F; VLA-6; ITGA6 |
| Location | Cell membrane |
| Accession | P23229、Q61739 |
| Clone Number | S-R707 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Hu, Ms |
| Positive Sample | Human peripheral blood lymphocytes |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu, Ms |
Background
CD49f, also known as integrin α6 subunit, is a type I transmembrane glycoprotein encoded by the ITGA6 gene. It belongs to the α-subfamily of integrins and can form heterodimers with β1 (CD29) or β4 (CD104) subunits to create functional receptors such as α6β1 or α6β4. These receptors play crucial roles in cell adhesion, migration, and signaling. CD49f is highly expressed in various cell types, including T cells, monocytes, platelets, epithelial cells, and certain stem cells. In cancer biology, CD49f has been identified as a marker for tumor-initiating cells (TICs) in hepatocellular carcinoma (HCC), where it is associated with cell stemness, immune evasion, and the formation of an immunosuppressive tumor microenvironment. Additionally, CD49f has been used as a marker for human astrocytes and has shown potential in studying neurodegenerative diseases.
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