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Description
Biotin Rat Anti-Mouse CD24 Antibody (S-R671)Product Specification Host Rat Antigen CD24 Synonyms Signal transducer CD24; Lymphocyte antigen 52 (Ly 52); M1 69 J11D heat stable antigen (HSA); Nectadrin; R13 Ag; X62 heat stable antigen; Cd24a; Ly 52 Location Cell membrane Accession P24807 Clone Number S R671 Antibody Type Rat mAb Isotype IgG2b,k Application FCM Reactivity Ms Positive Sample BALB c mouse bone marrow Purification Protein G Concentration 0. 05mg ml Conjugation Biotin Physical
Product Specification
| Host | Rat |
| Antigen | CD24 |
| Synonyms | Signal transducer CD24; Lymphocyte antigen 52 (Ly-52); M1/69-J11D heat stable antigen (HSA); Nectadrin; R13-Ag; X62 heat stable antigen; Cd24a; Ly-52 |
| Location | Cell membrane |
| Accession | P24807 |
| Clone Number | S-R671 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | BALB/c mouse bone marrow |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD24, also known as the heat-stable antigen (HSA) or small-cell lung carcinoma cluster 4 antigen, is a highly glycosylated protein anchored to the cell membrane via glycosylphosphatidylinositol (GPI). It is a small mucin-like molecule expressed in various cell types, including B cells, immune cells, and tumor cells. CD24 acts as a "don't eat me" signal by interacting with Siglec-10 on macrophages, inhibiting phagocytosis and promoting immune evasion in cancer. This protein is overexpressed in many solid tumors, such as breast, lung, and colorectal cancers, and is associated with tumor progression and poor prognosis. Unlike CD47, CD24 is not expressed on red blood cells, making it a promising target for cancer immunotherapy without the risk of blood toxicity. Current research focuses on developing CD24-targeted therapies, including monoclonal antibodies and nanoparticle-based delivery systems, to enhance anti-tumor immunity.
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