CD100/Semaphorin-4D Recombinant Rabbit mAb (S-3651-16)

CD100, also known as Semaphorin-4D (Sema4D), is a type I transmembrane glycoprotein belonging to the semaphorin family that functions as a critical bidirectional signaling molecule in both the nervous and immune systems. Originally identified for its role in axon guidance and neuronal development by repelling growth cones through its interaction with Plexin-B1 receptors, CD100 has since been recognized as a potent immunomodulator expressed on activated T cells, B cells, dendritic cells, and various tumor types. Upon cleavage by metalloproteinases, it releases a soluble form that retains biological activity, engaging primarily with Plexin-B1 on endothelial and tumor cells to promote angiogenesis, cell migration, and invasion, while also binding to CD72 on B cells to regulate their activation and differentiation. This dual functionality makes CD100/Sema4D a pivotal player in pathological processes such as tumor progression, metastasis, and inflammatory responses, thereby establishing it as a promising therapeutic target for cancer immunotherapy and autoimmune disease management.