SKU: 74327397550

PDGFRAlpha (5D1) Mouse mAb

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Description

PDGFRAlpha (5D1) Mouse mAbPlatelet derived growth factor (PDGF) family proteins exist as several disulphide bonded, dimeric isoforms (PDGF AA, PDGF AB, PDGF BB, PDGF CC, and PDGF DD) that bind in a specific pattern to two closely related receptor tyrosine kinases, PDGF receptor Alpha (PDGFRAlpha) and PDGF receptor Beta (PDGFRBeta). PDGFRAlpha and PDGFRBeta can each form heterodimers with EGFR, which is also activated by PDGF. Various cells differ in the total number of

Platelet derived growth factor (PDGF) family proteins exist as several disulphide-bonded, dimeric isoforms (PDGF AA, PDGF AB, PDGF BB, PDGF CC, and PDGF DD) that bind in a specific pattern to two closely related receptor tyrosine kinases, PDGF receptor Alpha (PDGFRAlpha) and PDGF receptor Beta (PDGFRBeta). PDGFRAlpha and PDGFRBeta can each form heterodimers with EGFR, which is also activated by PDGF. Various cells differ in the total number of receptors present and in the receptor subunit composition, which may account for responsive differences among cell types to PDGF binding. Ligand binding induces receptor dimerization and autophosphorylation, followed by binding and activation of cytoplasmic SH2 domain-containing signal transduction molecules, such as GRB2, Src, GAP, PI3 kinase, PLCGamma, and NCK. A number of different signaling pathways are initiated by activated PDGF receptors and lead to control of cell growth, actin reorganization, migration, and differentiation.

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SKU: 74327397550

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4.3 ★★★★★
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Verified Purchase
Amazon Customer
Birmingham, US
★★★★★ 5
Very good quality for a reasonable price.
Size: 10, Color: Grey
Very good quality, very soft, very comfortable, look amazing, I’m very happy.
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Reviewed in the United States on May 23, 2026
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Verified Purchase
Mike L.
Phoenix, US
★★★★★ 4
Comfortable fit for slip-in fabric shoes
Size: 14, Color: Black/Black
My first experience with Marc Joseph. I typically purchase dress and casual work shoes from Florsheim and occasionally Rockport. I'm giving these four stars because the initial fit and feel appear solid. Depending on the shoe brand I wear a size 14 or 15. My feet are slightly wide but I don't alway need wide fit. These size 14 fit well with wide enough toe box. I've tried slip in shoes before and they just don't feel right. These somehow work and there is no heel slip. My only reservation is the high lip on the heel for slip-in and hope they dont catch pant hems. I gave 4 stars because I'll have to determine durability. Granted they are a light fabric shoe with a soft rubber tread. I'd like them to last for at least 6 months..and use them for business casual work wear during warm weather.
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Reviewed in the United States on May 19, 2026
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Verified Purchase
Chris
Pawtucket, US
★★★★★ 5
Stylish and comfortable.
Size: 8 Wide, Color: Black/Black
Shoes look great and fits well. Definitely recommend pocking another pair.
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Reviewed in the United States on May 10, 2026
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Verified Purchase
Mike
Belleville, US
★★★★★ 3
Narrow for an 11.5W
Size: 11.5 Wide, Color: Navy
Nice look and material but very narrow for a wide, had to return
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Reviewed in the United States on February 25, 2026
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David Kuck
Boise, US
★★★★★ 5
NIce Shoes
Size: 10, Color: Black
Very nice quality and comfort
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Reviewed in the United States on June 1, 2026

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