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Ships within 48 hours · Estimated delivery Sep 18 - Sep 23
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Description
EGFR Mouse mAbThe epidermal growth factor receptor (EGFR; ErbB 1; HER1 in humans) is the cell surface receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands. Known ligands include EGF, TGFA TGF alpha, amphiregulin, epigen EPGN, BTC betacellulin, epiregulin EREG and HBEGF heparin binding EGF. Ligand binding triggers receptor homo and or heterodimerization and autophosphorylation on key cytoplasmic residues. The
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades.
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