SKU: 33697896213

Chiral Photochemical Scissors Targeting Proteins

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Description

Chiral Photochemical Scissors Targeting ProteinsThe remarkable ability to target one or even a couple of sites on a large protein with a small molecule, under photochemical control, is a considerable challenge and this challenge has been addressed in some depth in this book. Systematic modification of the structure of the photoreagent provided valuable information on the binding site recognition as well as the mechanism of the photocleavage reaction. Some factors that impact the photocleavage

The remarkable ability to target one or even a couple of sites on a large protein with a small molecule, under photochemical control, is a considerable challenge and this challenge has been addressed in some depth in this book. Systematic modification of the structure of the photoreagent provided valuable information on the binding site recognition as well as the mechanism of the photocleavage reaction. Some factors that impact the photocleavage reaction include the exact location of the probe binding site on the protein, conformations of the bound probe at the binding site, protein size, functional groups present on the probe that interact with the protein surroundings either in a favorable or unfavorable manner, overall charge on the photoreagent, and photophysical as well as photochemical properties of the probe. The protein photocleavage studies, in all case, were preceded by detailed binding studies by a variety of spectroscopic methods. Methods as simple as absorption and fluorescence spectroscopies or more sophisticated circular dichroism spectroscopy were used. Conclusions that are most consistent with the binding data indicated a single binding site on most proteins, irrespective of the probe or the protein, with only one exception noted so far. Photoactivation of the bound probe resulted in protein cleavage at a single site, in many instances. The specificity for the reaction has been investigated in detail and molecular modeling studies provided a firm ground to rationalize the observed cleavage sites. The reagents provide unique tools for sequencing large proteins by converting them into smaller fragments by non-biochemical transformations. Understanding of the rules for the above methodology are also investigated which provided rational methods for the design of small molecules that could bind at particular sites on large proteins, and this is a major breakthrough for a variety of fields including drug design, protein targeting, mass spectrometry, proteomics and other cutting-edge research areas.

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SKU: 33697896213

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Mckimisah
Whiting, US
★★★★★ 4
Nice and bright
Color: Orange, Size: MINI 1.75" - 4 Pack
These are great to fit the ball shooter I use with my dogs. Color orange makes it easy to find in grass or dirt. Problem is I have a chewer. He loves to chew on the ball and eat the orange fiber. So, the balls get wrecked and I have to replace. Gets costly. I wish they made this same size ball without the orange furry tennis-ball like covering. Maybe the toys would last longer.
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Reviewed in the United States on April 21, 2026
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Thorne Donnelley Jr.
Fort Morgan, US
★★★★★ 5
Safe for dogs
Color: Green, Size: Regular 2.5" - 4 Pack
Much better for dogs than used/dirty tennis balls. Worth the money for safety.
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Reviewed in the United States on May 27, 2026
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Cassy
Massapequa, US
★★★★★ 3
Easily breakable coating/fur
Color: Pink, Size: MINI 1.75" - 4 Pack
I wanted to love this item but sadly my dog really messed up the coating/fur on these balls so easily, other than that great product but with her being a puppy I got these smaller ones for that reason and I’m absolutely scared of her destroying things and getting stomach issues, so it’s just not worth it to me.
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Reviewed in the United States on April 20, 2026
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Jorgigirl
Natrona Heights, US
★★★★★ 5
Perfect size
Color: Orange, Size: MINI 1.75" - 4 Pack
These were the perfect size for my ball chasing kittens. they love scuffing up the balls and carrying them around the house or bringing them to me to play fetch. Yes, my cats love to play fetch.
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Reviewed in the United States on May 12, 2026
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DONALD BRYANT
Lake Worth, US
★★★★★ 4
Fun with dog
Color: Green, Size: MINI 1.75" - 12 Pack
Had these for about 3 weeks using them multiple times daily and they seem to hold up, the dog loves the chase!
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Reviewed in the United States on May 20, 2026

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