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Description
human bcrp vesicle kit hek293Das Human BCRP Vesicle Kit enthlt Inside out Membranvesikel aus HEK293 Zellen, die transient das Breast Cancer Resistance Protein (BCRP ABCG2) berexprimieren. Das Kit ermglicht ATP abhngige Substrattransportstudien im High Throughput Format und ist konform mit den FDA (2017) und EMA (2013) Leitlinien zur Charakterisierung von Arzneimittelwechselwirkungen (DDI). Hergestellt von Cell4Pharma. Exklusiv im DACH Raum erhltlich ber SeamlessBio. Transporter
Das Human BCRP Vesicle Kit enthält Inside-out-Membranvesikel aus HEK293-Zellen, die transient das Breast Cancer Resistance Protein (BCRP / ABCG2) überexprimieren. Das Kit ermöglicht ATP abhängige Substrattransportstudien im High-Throughput-Format und ist konform mit den FDA (2017)- und EMA (2013)-Leitlinien zur Charakterisierung von Arzneimittelwechselwirkungen (DDI).
Hergestellt von Cell4Pharma. Exklusiv im DACH-Raum erhältlich über SeamlessBio.
Transporter-Profil
Name: BCRP, Breast Cancer Resistance Protein, ABCG2, ATP-bindende Kassette Unterfamilie G Mitglied 2
Gen: ABCG2
ATP/AMP-Ratio: >10 (garantiert)
Gewebsexpression: Plazenta, Stammzellen, Prostata, Dünndarm, Gehirn, Dickdarm, Leber, Brustdrüse, Niere
Bekannte Substrate: Estron-3-Sulfat (E1S), Methotrexat, Irinotecan, Pantoprazol, Rosuvastatin, Topotecan, Chlorothiazid, Mitoxantron, SN-38, Glibenclamid
Kit-Inhalt (100 Reaktionen)
- Vesikel-Vial (100 Reaktionen), BCRP-überexprimierende
- HEK293-abgeleitete Vesikel
- AMP-ATP-Lösung (100 mM), Cell4Pharma
- Assay-Puffer, Cell4Pharma
Anwendungen
- Identifikation von Efflux-Transporter-Substraten
- Drug-Drug-Interaction-(DDI)-Studien gemäß FDA/EMA-Leitlinien
- Inhibitionsstudien (IC50-Bestimmung)
- High-Throughput-Screening (Radiolabel-, Fluoreszenz-, LC-MS-Detektion)
Regulatorische Konformität
Der vesikuläre Transportassay mit BCRP-Vesikeln wird im FDA Drug
Interaction Guidance (2017) und in der EMA-Leitlinie zur Untersuchung von
Arzneimittelinteraktionen (2013) für die Charakterisierung
transporter-vermittelter DDI in der Arzneimittelentwicklung empfohlen.
Technische Spezifikationen
Wirtszelle: HEK293 (humane embryonale Nierenzelle)
Vesikeltyp: Inside-out-Membranvesikel
Format: 100 Reaktionen pro Kit
Detektion: Radiolabel / Fluoreszenz / LC-MS kompatibel
Lagerung: –80 °C
Verwandte Produkte
- Human Control Vesicle Kit (C4PVK009) – empfohlen als Negativkontrolle in BCRP-Transportassays
- Human Pgp Vesicle Kit (C4PVK010) – für parallele P-gp-Efflux-Messung
- ciPTEC-OAT1 Assay-Ready Cells – für zellbasierte Nephrotoxizitäts- und Transporterstudien
- Human Serum AB Male OTC (SeamlessBio) – zur Supplementierung von ciPTEC-Kulturmedien
Alle Produkte auf Anfrage.
Kontakt: [email protected] | Telefon: +49 851 37932226
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Nice boys undershirts
Size: Medium, Color: White - 10 Pack
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Reviewed in the United States on February 21, 2026
★★★★★ 5
Tees
Size: Medium, Color: White - 10 Pack
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Size: Small, Color: White - 10 Pack
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Reviewed in the United States on August 25, 2025
★★★★★ 5
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Size: Medium, Color: White - 10 Pack
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Reviewed in the United States on April 7, 2026