Pay in installments of $181.25 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Sep 15 - Sep 20
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
mrp5 vesicle kitHuman MRP5 Vesikel Kit Inside Out Membranvesikel fr ubiquitre organische Anionen und zyklische Nukleotid Transportstudien Das Human MRP5 Vesikel Kit (HEK293 abgeleitet) liefert gebrauchsfertige Inside Out Membranvesikel fr ATP abhngige Transportstudien von MRP5 (ABCC5). Im Gegensatz zu anderen MRPs mit organspezifischer Expression wird MRP5 ubiquitr im Krper exprimiert und verarbeitet zyklische Nukleotide, Nukleotidanaloga und organische Anionen. Es
Human MRP5 Vesikel-Kit – Inside-Out-Membranvesikel für ubiquitäre organische Anionen- und zyklische Nukleotid-Transportstudien
Das Human MRP5 Vesikel-Kit (HEK293-abgeleitet) liefert gebrauchsfertige Inside-Out-Membranvesikel für ATP-abhängige Transportstudien von MRP5 (ABCC5). Im Gegensatz zu anderen MRPs mit organspezifischer Expression wird MRP5 ubiquitär im Körper exprimiert und verarbeitet zyklische Nukleotide, Nukleotidanaloga und organische Anionen. Es ist besonders relevant für antivirale und onkologische Nukleosidanaloga und wurde an der Blut-Hirn-Schranke identifiziert.
Transporterprofil
MRP5 (ABCC5) wird ubiquitär in Herz, Gehirn, Skelettmuskel, Hoden und vielen anderen Geweben exprimiert. Es transportiert zyklische Nukleotide (cAMP, cGMP), organische Anionen, Glutathionkonjugate und Nukleosidmonophosphat-Analoga. Seine breite Gewebeverteilung bedeutet, dass MRP5-Hemmung potenziell die Arzneimittelverteilung in mehreren Kompartimenten beeinflussen kann. Wichtige Substrate: cAMP, cGMP, PMEA, Fluoreszein. Weniger gut charakterisiert als MRP1–4; dieses Kit ermöglicht systematisches in-vitro-Profiling.
Technische Spezifikationen
| Parameter | Spezifikation |
|---|---|
| Transporter | Human MRP5 (Multidrug Resistance-Associated Protein 5) (ABCC5) |
| Expressionssystem | HEK293 (transiente Überexpression) |
| Vesikeltyp | Inside-Out-Membranvesikel |
| Reaktionen pro Kit | 100 |
| ATP/AMP-Transportverhältnis | >5 |
| Detektionskompatibilität | Radiolabel, LC-MS/MS |
| Lagerung | −80 °C (Lieferung auf Trockeneis) |
| Kit-Inhalt | Vesikel, ATP, AMP, Reaktionspuffer, Waschpuffer, CoA |
| Hersteller | Cell4Pharma (Netherlands) |
| Distributor DACH | SeamlessBio GmbH, Passau |
Anwendungsgebiete
| Anwendung | Beschreibung |
|---|---|
| Nukleosidanalogon-Transport-Profiling | Screening onkologischer und antiviraler Nukleosidmonophosphat-Analoga als MRP5-Substrate — relevant für das Verständnis der intrazellulären Arzneimittelakkumulation und Resistenzmechanismen. |
| ZNS-Arzneimittelverteilung | MRP5-Expression an der Blut-Hirn-Schranke kann zur eingeschränkten ZNS-Penetration organischer Anionen beitragen. Relevant für ZNS-Arzneimittelentwicklungsprogramme. |
| Breites Gewebeverteilungs-Profiling | Charakterisierung des MRP5-vermittelten Efflux in Nicht-Leber-, Nicht-Darm-Geweben — kardiale, testiculäre und ZNS-Kompartimente, wo ubiquitäre Expression pharmakologisch relevant ist. |
Assay-Prinzip
Inside-Out-Membranvesikel präsentieren die zytoplasmatische Seite des Transporters dem Assaypuffer und ermöglichen so ATP-abhängige Substrataufnahme in das Vesikelinnere. Vesikel mit Testverbindung und Probesubstrat in Gegenwart von ATP (Transport) oder AMP (Hintergrundkontrolle) inkubieren. Reaktion mit kaltem Waschpuffer stoppen, Vesikel durch Filtration trennen und akkumuliertes Substrat per LC-MS/MS, Radiolabel oder Fluoreszenz quantifizieren. Das ATP/AMP-Verhältnis bestimmt das Assay-Fenster für die zuverlässige IC₅₀-Bestimmung.
Komplettes Cell4Pharma Kit-Portfolio bei SeamlessBio
Alle ABC-Transporter-Vesikel-Kits aus einer europäischen Quelle — schnelle Kühlkettenlieferung, garantierte ATP/AMP-Verhältnisse, vollständige Dokumentation.
| Kit | Transporter | Gen | ATP/AMP-Verhältnis |
|---|---|---|---|
| Human BCRP Vesicle Kit | BCRP | ABCG2 | >10 |
| Human BSEP Vesicle Kit | BSEP | ABCB11 | >10 |
| Human MRP1 Vesicle Kit | MRP1 | ABCC1 | >5 |
| Human MRP2 Vesicle Kit | MRP2 | ABCC2 | >20 |
| Human MRP3 Vesicle Kit | MRP3 | ABCC3 | >5 |
| Human MRP4 Vesicle Kit | MRP4 | ABCC4 | >5 |
| Human MRP5 Vesicle Kit | MRP5 | ABCC5 | >5 |
| Human MRP8 Vesicle Kit | MRP8 | ABCC11 | >5 |
| Human Pgp Vesicle Kit | P-gp / MDR1 | ABCB1 | >5 |
| Human Pgp + FluoPgp Kit | P-gp / MDR1 | ABCB1 | >5 |
| Human Control Vesicle Kit | — | HEK293 empty vector | — |
Qualität & Regulatorische Konformität
- Produziert von Cell4Pharma — Spezialhersteller für ABC-Transporter-Vesikelsysteme
- Garantiertes ATP/AMP-Transportverhältnis >5 pro Charge
- Große, einheitliche Chargen — maximale Lot-zu-Lot-Konsistenz
- Chargenspezifischer QC-Bericht + Datenblatt bei jedem Kit inklusive
- Konform mit FDA DDI Guidance (2020) und EMA DDI Guideline (2013/2022)
Warum über SeamlessBio bestellen?
| Vorteil | Beschreibung |
|---|---|
| ✅ EU-Lagerverfügbarkeit | Schnelle Kühlkettenlieferung in Deutschland, Österreich, Schweiz und der EU |
| ✅ Direktkontakt | Direkter Kontakt zum Fachberater — auf Deutsch oder Englisch |
| ✅ Vollständige Dokumentation | Datenblatt, QC-Bericht und Rechnung bei jeder Lieferung |
| ✅ Chargenreservierung | Spezifische Charge für die gesamte Projektlaufzeit reservieren |
| ✅ Komplettes Portfolio | Alle 11 Cell4Pharma Kits aus einer Quelle — BCRP, BSEP, MRP1–8, Pgp, Kontrolle |
Bestellung oder Preisanfrage: [email protected] | +49 851 37932226
Häufige Fragen
Wie unterscheidet sich MRP5 von MRP4 bei der Substratselektivität?
MRP4 und MRP5 teilen einige Substrate (cAMP, cGMP, PMEA), unterscheiden sich aber in Expressionsmustern und Transportkinetik. MRP4 ist mehr renal-dominant; MRP5 ist ubiquitär mit besonders bemerkenswerter ZNS/Herz-Expression. Das parallele Laufen beider Kits bietet umfassendes Nukleotidanalogon-Profiling.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy
4.7 ★★★★★
Based on 12 reviews
Sort
Product Reviews
★★★★★ 5
Simple, Comfortable, and Exactly What You Expect
Style: Rack with 3 Pairs (5, 10, and 15 Pound)
These are pretty much exactly what you want from a set of dumbbells — simple, functional, and no nonsense. The neoprene coating gives them a comfortable grip and keeps them from feeling slick in your hands, especially during longer workouts or if your hands get sweaty.
The coating also helps keep them from banging up floors or making as much noise compared to bare metal weights, which is nice if you’re working out at home.
Weight accuracy seems fine for general fitness use, and they’ve worked great for things like accessory movements, shoulder work, lighter presses, rehab-style exercises, and general muscle toning. The shape also helps keep them from rolling around everywhere when set down.
They’re not fancy, and they’re not trying to be — they’re just dependable dumbbells that do what they’re supposed to do at a fair price.
If you want straightforward hand weights for home workouts without overthinking it, these are a solid buy.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 26, 2026
★★★★★ 5
Reliable, Comfortable Dumbbells I Actually Use Every Day
Style: 12 Pound, Pair, Style: 12 Pound, Pair
I’ve been using the Amazon Basics Neoprene Dumbbell Hand Weights daily, and they’ve honestly been perfect for my routine. Whether I’m doing a quick morning workout or adding resistance to a longer session, these have held up really well.
The neoprene coating makes a big difference—it provides a comfortable, non-slip grip, even during longer workouts or when my hands get a little sweaty. They’re also easy to clean and don’t have that strong rubber smell some weights can have.
I really appreciate the hex shape too. They stay put when I set them down (no rolling across the floor), which makes switching between exercises quick and frustration-free. The weight feels evenly distributed and well-balanced, so movements feel controlled and smooth.
Overall, these are simple, no-frills dumbbells that just work. If you’re looking for reliable hand weights for everyday use—whether you’re a beginner or just need something dependable for home workouts—these are a great choice.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 14, 2026
★★★★★ 5
Great quality and perfect for home workouts!
Style: Rack with 3 Pairs (3, 5, and 8 Pound)
I’m really happy with this dumbbell set. The weights are clearly labeled (3 lb, 5 lb, and 8 lb), which makes it super convenient to switch between exercises. The neoprene coating feels comfortable in hand and provides a good grip, even during longer workouts.
The storage stand is a big plus—it keeps everything organized and saves space, which is perfect for a small home gym. The colors are also nice and make it easy to quickly grab the weight you need.
Overall, this is a great set for beginners or anyone looking to add light strength training to their routine. Highly recommend!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 13, 2026
★★★★★ 5
I’m A PT AND USING THEM IN MY CLINIC. PLS READ HONEST AND THOROUGH REVIEW.
Style: 15 Pound, Pair
I have been a PHYSICAL THERAPIST FOR 30 YEARS and I BOUGHT THESE FOR MY CLINIC. THESE WEIGHTS ARE COVERED IN A GRIPPING MATERIAL, NEOPRENE, MAKING IT COMFORTABLE and EASIER TO USE, ALLOWS YOU TO NOT LOSE YOUR GRIP, and IT IMPROVES THE SAFETY OF THE USER. I WILL BE BUYING THE 12&20 lb sets! THE VALUE FOR YOUR MONEY IS WONDERFUL!! AMAZON BASICS REALLY CAME THROUGH. It DID NOT INCLUDE AN INSTRUCTION GUIDE TO USE WEIGHTS SAFELY AND EFFECTIVELY. STELLAR FORM IS ALWAYS ESSENTIAL.
MY WEIGHTS WENT UP TO 10 POUNDS, SO I DEFINITELY NEEDED ADDITIONAL WEIGHTS for those who can SAFELY TRANSITION . I MAINLY WORK AS A MANUAL THERAPIST …USING ONLY MY HANDS, AND MY BRAIN. TO DIAGNOSE AND TREAT ACCORDINGLY.
(**ANYONE WHO HAS BEEN TO PT KNOWS THIS KIND OF ONE ON ONE TREATMENT IS UNHEARD OF**)
I IMPLEMENTED MYOFASCIAL RELEASE, TRIGGER POINT THERAPY, DEEP TISSUE MASSAGE, AND APPROPRIATE STRETCHING AND EXERCISE . ONCE PATIENTS WERE ABLE, I INITIATED THERAPEUTIC EXERCISE. I WAS GETTING SO MANY REFERRALS THAT I MOVED FROM MY SMALL SPACE AND GOT A LARGER SPACE THAT LOOKS LIKE A TYPICAL PT CLINIC. I STILL EMPLOY ONE ON ONE TREATMENT, NO JUGGLING SEVERAL PATIENTS IN AN HOUR. I HAVE HIRED HELP TO ASSIST PATIENTS WITH EXERCISE AND STRETCHING. I PURCHASED TWO ADDITIONAL SETS ITHE SET IT I DID TO FIRST CHECK THEM OUT. I ADORE THESE AND HAVE SINCE ORDERED OTHER SETS. I LOVE TO WORKOUT AND I NEEDED TO USE THESE WEIGHTS MYSELF!! THERE ARE ALSO PATIENTS OF MINE WHO WILL PROGRESS TO THESE AS WELL. I AM SUPER IMPRESSED WITH THESE WEIGHTS AND CANNOT WAIT TO RECEIVE MY TWO OTHER SETS!! YOU WILL NOT BE DISAPPOINTED.
EVEN IF YOU SWEAT, YOU ARE STILL ABLE TO HOLD ONTO THESE WEIGHTS COMFORTABLY AND SAFELY. SAFETY IS KEY, ALWAYS. I WAS EXTREMELY DELIGHTED THAT THEY ARE SOLD AS A SET BECAUSE MANY ARE SOLD SEPARATELY. THEY FIT PROPERLY ON A UNIVERSAL WEIGHT STAND, SO THEY ARE VERY EASY TO STORE. I CANT WAIT TO GET MY OTHER SETS! IT IS REALLY SAFE AND COMFORTABLE TO USE THESE WEIGHTS.
THEY DID NOT GIVE OFF AN ODD ODOR, which is A HUGE PLUS because SOME OTHER BRANDS SMELL HEAVILY OF PLASTIC OR A CHEMICAL TYPE ODOR. THERE WAS NO ODOR AT ALL. THIS IS A HUGE PLUS. I AM COMFORTABLE SAYING THAT THESE WEIGHTS WILL LAST A LONG TIME BECAUSE OF HOW WELL THEY ARE MADE. YOU CANNOT BEAT THE PRICE EITHER!!
THESE ARE ABSOLUTELY APPROPRIATE FOR PROFESSIONAL USE, AND, THEY ARE MEANT FOR PERSONAL USE AS WELL. SOMETIMES YOU JUST CANNOT GET TO THE GYM SO THIS IS WHERE THEY ARE KEY. HAND WEIGHTS HAVE THE ABILITY TO EXERCISE EACH MUSCLE OF THE TORSO AND ARMS. THERE ARE SOME EXCELLENT WEIGHT CHARTS OUT THERE TO SHOW YOU HOW TO DO THAT. IF YOU ARE GOING TO PHYSICAL THERAPY, THEN YOUR THERAPIST CAN INSTRUCT YOU AND KEEP YOU IN GOOD FORM. YOU COULD POSSIBLY HURT YOURSELF IF YOU WORKOUT INCORRECTLY. AS FAR AS THE LOWER EXTREMITIES, YOU CAN DO GROSS MOTOR EXERCISES BY HOLDING THESE WEIGHTS TO GET YOUR LEG MUSCLES BY DOING SQUATS, WALKING LUNGES, TOE RAISES, AND MORE. I DONT BELIEVE THAT MANY PEOPLE REALIZE JUST HOW MUCH YOU CAN DO FULL BODY EXERCISES WITH JUST TWO HAND WEIGHTS.
IN CONCLUSION , THESE ARE EXCELLENT WEIGHTS THAT I WOULD RECOMMEND TO MY PATIENTS OR FRIENDS. THIS IS A HIGH QUALITY PRODUCT THAT WONT BREAK YOUR PIGGY BANK. I HIGHLY RECOMMEND VERY HIGHLY!. BUY WITHOUT RESERVATION!! A+++
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 23, 2025
★★★★★ 4
Perfect size and weight with compact size
Style: Rack with 3 Pairs (3, 5, and 8 Pound)
I purchased the Amazon Basics Neoprene Dumbbell Hand Weights specifically for Pilates, and they’ve been a great addition to my routine. The size and weight are perfect for controlled movements, helping with muscle toning without feeling too bulky or awkward.
The neoprene coating gives them a comfortable, non-slip grip, which is especially important during longer sessions or when your hands get a little sweaty. They feel secure and easy to hold through a full workout.
I also like the shape—they don’t roll around on the floor, which makes transitions between exercises smoother and less frustrating. They’re compact enough to store easily but still feel durable and well-made.
Overall, these are a simple, affordable, and effective option for Pilates or light strength training. I’d definitely recommend them for anyone looking to add a little resistance to their workouts without overcomplicating things.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 20, 2026
recommand products
Teppich Kurzflor beige rosa "Cloud7" WECONhome
39.00
Esprit Kelim Beige Taupe aus Wolle "Natham"
69.00
Kate Wolken Frühling Hintergrund Cake Smash Kinder Geburtstag von Rose Abbas
54.90
Kate Kombibackdrop Geburtstag Porträt Retro Holz Hintergrund
41.90
Kate Winter Holz Hintergrund Schnee Weihnachten Fenster von Chain Photography
41.90